• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

Melatonin modulates 900 MHz microwave-induced lipid peroxidation changes in rat brain. med./biol.

PubMed Entry

Journal web site

Aim of study (according to author)
To determine the effects of microwaves on the brain lipid peroxidation system (in hippocampus and cortex), and the possible protective effects of melatonin on brain degeneration induced by microwaves.
Background/further details:
Male rats were divided into three groups: 1) sham-exposed control group (n = 8); 2) 900 MHz microwave exposed group (n = 8), and 3) 900 MHz microwave exposed + melatonin group (100 µg/kg before daily exposure) (n = 10).

Endpoint

• effects on the neurological system: oxidative damage/lipid peroxidation in the brain

Exposure
General category: digital mobile phone, GSM, microwaves

Field characteristics	Parameters
900 MHz pulsed (PW) exposure duration: repeated daily exposure, 30 min/day, 5 days/week, for 2 weeks	power: 2 W peak value power flux density: 1.04 mW/cm² SAR: 0.016 W/kg average over mass (whole body) SAR: 4 W/kg max value (in the head)

Exposed system:
animal (species/strain): rat/Sprague-Dawley
partial body exposure: head

Methods
Endpoint/Measurement parameters/Methodology

• effects on the neurological system: oxidative damage/lipid peroxidation in the brain (via malondialdehyde; absorption measurement)

Main outcome of study (according to author)
The levels of lipid peroxidation in the cortex and hippocampus increased in the exposed group compared with the control group, although the levels in the hippocampus were decreased by "microwave+melatonin" administration. The cortex lipid peroxidation levels were unaffected by melatonin treatment.
The authors conclude that melatonin may prevent microwave-induced oxidative changes in the hippocampus by strengthening the antioxidant defense.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

• not stated

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