• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

Does 900 MHz GSM Mobile Phone Exposure Affect Rat Brain? med./biol.

Journal web site

Aim of study (according to author)
To study the effects of cell phone exposure on the fatty acid composition in phospholipids, malondialdehyde concentration, p53 immune reactivity and histological structure of the rat brain.
Background/further details:
It is suggested that p53 immune reactivity may be related to the change of fatty acid composition in phospholipids. The loss of p53 appears to sensitize cells to fatty acid synthase inhibitors, and raises the possibility that these agents may be clinically useful against malignancies.
Malondialdehyde is a marker for lipid peroxidation, free radical damage, and oxidative stress. Lipid peroxidation may induce p53 immune reactivity.

Endpoint

• effects on the neurological system: fatty acid composition in phospholipids, malondialdehyde concentration, p53 immune reactivity and histological structure of the brain

Exposure
General category: digital mobile phone, GSM

Field characteristics	Parameters
890 - 915 MHz pulsed (PW) exposure duration: repeated daily exposure, 20 min/day for 1 month	power: 2 W peak value power: 250 mW mean value electric field strength: 13.59 V/m mean value power flux density: 0.047 mW/cm² mean value SAR: 3.13 W/kg effective value (1 g) SAR: 0.52 W/kg effective value (whole body) (0.29-0.87 W/kg)

Exposed system:
animal (species/strain): rat/Sprague-Dawley
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

• molecular biosynthesis: malondialdehyde concentration
• effects on immunological system: p53 immune reactivity (immunohistochemistry)
• morphological/histopathological changes: histological structure (hematoxylin-eosin stain; light microscopy)
• effects on the neurological system: fatty acid composition (see "others"), malondialdehyde content (see "molecular biosynthesis"), p53 immune reactivity (see "effects on immunological system") and histological structure (see "morphol./histopathol. changes") of the brain
• others: fatty acid composition in phospholipids (gas chromatography)

Main outcome of study (according to author)
Histological alteration and changes in brain phospholipid fatty acids composition were not found in the brains. p53 immune reactivity was not affected by cell phone exposure. Malondialdehyde concentration in exposed brains was significantly higher than in sham-exposed brains. The alteration in malondialdehyde does not appear sufficient to induce histological changes in brain tissue.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

• not stated

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