• experimentell
  
• epidemiologisch
  

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Medizinisch/biologische Studie (experimentelle Studie)

Studying gene expression profile of rat neuron exposed to 1800 MHz radiofrequency electromagnetic fields with cDNA microassay. med./biol.

PubMed Eintrag

Journal Website

Ziel der Studie (lt. Autor)
Es sollte untersucht werden, ob hochfrequente 1800 MHz elektromagnetische Felder die Genexpression von Neuronen beeinflussen können.
Hintergrund/weitere Details:
Zerebrale kortikale und hippokampale Gewebe wurden aus drei Sprague-Dawley-Ratten gewonnen.

Endpunkt

• molekulare Biosynthese: Genexpression

Exposition/Befeldung
Allgemeine Kategorie: digitales Mobiltelefon, GSM

Feldeigenschaften	Parameter
1800 MHz gepulst (PW) Expositionsdauer: intermittierend, 5 min an/10 min aus, für 24 h	SAR: 2 W/kg Mittelwert

Exponiertes System:
intakte Zelle/Zellkultur (in vitro)

Methoden
Endpunkt/Messparameter/Methodik

• molekulare Biosynthese: Genexpression (Affymetrix Rat Neurobiology U34 cDNA-Microarray; RT-PCR)

Hauptergebnis der Studie (lt. Autor)
Von den 1200 Kandidatengenen wurden nach Exposition 24 hochregulierte und 10 runterregulierte Gene identifiziert, die mit einer Vielzahl zellulärer Funktionen verbunden sind. Die Ergebnisse wurden darüber hinaus durch RT-PCR bestätigt. Die Daten deuten darauf hin, dass die Genexpression von Ratten-Neuronen durch eine Exposition bei hochfrequenten elektromagnetischen Feldern unter den vorliegenden experimentellen Bedingungen verändert werden könnte.

(Studienmerkmale: medizinisch/biologische Studie, experimentelle Studie, Voll-/Hauptstudie)

Studie gefördert durch

• National Natural Science Foundation (NSFC), China

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