Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus, and sister chromatid exchange analyses med./bio.

[Fehlen von Genotoxizität in menschlichen Blut-Zellen, exponiert bei 50 Hz Magnetfeldern, abgeschätzt durch Comet Assay, Chromosomenaberration, Mikronukleus- und Schwesterchromatidaustausch-Analysen]

Ziel der Studie (lt. Autor)

Endpunkt

• Genotoxizität/Mutation: DNA-Schäden

Exposition/Befeldung (teilweise nur auf Englisch)

• • 50/60 Hz
  • magnetisches Feld
• • Ko-Exposition

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• Genotoxizität/Mutation: DNA-Schäden (alkalischer Comet Assay (Komet-Moment: Schweiflänge x Anteil DNA im Schweif (% Schweif-DNA)); zytogenetischer Test, Schwesterchromatid-Austausch und Chromosomenaberration (Metaphase-Analyse); Mikronukleus-Test (MN-Häufigkeit, Giemsa-Färbung)
• Zelllebensfähigkeit/Zellteilung/Zellproliferation: Kernteilungsindex; Proliferationsindex (Anteil der Zellen, die sich 1, 2 oder 3x teilen; Metaphase-Analyse)

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• Ministero dell'Ambiente e della Tutela del Territorio e del Mar (Ministry of Environment and Territory), Italy

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• Scarfi MR et al. (1997): 50-Hz, 1-mT sinusoidal magnetic fields do not affect micronucleus frequency and cell proliferation in human lymphocytes from normal and Turner's syndrome subjects