Medical/biological Study (experimental study)
The Effects of Single and Repeated Exposure to 2.45 GHz Radiofrequency Fields on c-Fos Protein Expression in the Paraventricular Nucleus of Rat Hypothalamus. med./biol. By: Jorge-Mora T, Misa-Agustino MJ, Rodriguez-Gonzalez JA, Jorge-Barreiro FJ, Ares-Pena FJ, Lopez-Martin E
Published in: Neurochem Res 2011; 36 (12): 2322 - 2332 ( PubMed Entry , Journal web site )
Aim of study (according to author and editor)
To study the effects of radiofrequency exposure resulting in non-thermal (< 4 W/kg) specific absorption rates on c-Fos expression in the
paraventricular nucleus (of the hypothalamus) of rats.
60 female rats were divided into the following groups: 1) 20 rats were divided into three subgroups and exposed at 0, 3 and 12 W for 30 min. The rats were killed 90 min following exposure (when maximum c-Fos protein expression occurs). 2) 20 rats were divided into three subgroups and exposed at 0, 3 and 12 W for 30 min. The rats were killed 24 h following exposure. 3) 20 rats were exposed at 3 W for 30 min per day for a total of ten times in a two week period.
- effects on the neurological system: c-Fos expression in different regions of the paraventricular nucleus of the hypothalamus (as marker for neuronal activation)
General category: radio frequency field, 2.45 GHz
FIELD View further expo parameters
animal (species/strain): rat/Sprague-Dawley
whole body exposure
investigated material: tissue slices (in vitro)
- effects on the neurological system: c-Fos expression in different regions of the paraventricular nucleus (lateral magnocellular, medial parvocellular and ventral or lateral parvocellular; number of c-Fos-positive neurons; immunohistochemistry)
investigated organ system: brain/CNS
time of investigation: after exposure
Main outcome of study (according to author)
A high SAR value induced an increase of the c-Fos expression 90 min or 24 h after exposure, and a low SAR value resulted in higher c-Fos expression than in control rats after 24 h. Repeated irradiation at 3 W increased cellular activation of the paraventricular nucleus by more than 100% compared to animals subjected to acute exposure or to repeated sham exposed animals.
The data suggest that the paraventricular nucleus is sensitive to 2.45 GHz microwave exposure at non-thermal SAR levels.
(Study character: medical/biological study, experimental study, full/main study)
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Glossary: acute exposure, animals, biological, brain, c-Fos, cellular, CNS, electric field strength, endpoint, exposed, exposure, expression, full/main study, GHz, hypothalamus, immunohistochemistry, induced, in vitro, irradiation, lateral, marker, mean value, microwave, neurological, Neurons, non-thermal, nucleus, power, protein expression, radiofrequency, rat/Sprague-Dawley, rats, SAR, sham exposed, species, strain, tissue, ventral, whole body exposure
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