Study type:
Medical/biological study
(experimental study)
Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields
med./bio.
By:
Saha S, Woodbine L, Haines J, Coster M, Ricket N, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P
Published in: J R Soc Interface 2014; 11 (100): 20140783
Up to four pregnant mice were exposed to acutedoses of 10, 25, 50, 100 and 200 mGy of X-rays or under different exposure conditions to a magnetic field and sham exposure, respectively. Cage controls were conducted in parallel to each treatment. Subsequently, the animals were sacrificed, fetuses were removed and cryosections of the investigated brain areas were produced and investigated. For each exposure condition and control, two sections from each of three embryos from each of three mothers (a total of 18 sections) were analyzed.
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