The effects of exposure of osteoporotic and healthy rats to a 50 Hz magnetic field on bone micro-architecture and fracture healing should be investigated.
15 young rats were divided into two groups: 1) bilateral ovariectomy (to induce osteoporosis) (n=8) and 2) sham ovariectomy (n=7). 19 days after (sham) ovariectomy, a bilateral fibula fracture was generated in all rats. 2 days after fracture generation, exposure to the magnetic field started. Only one leg was exposed, respectively, the other leg was wrapped in copper foil for protection against the field and served as the control.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
continuous for 3 h/day on 5 days/week for 6 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | continuous for 3 h/day on 5 days/week for 6 weeks |
| Exposure source |
|
|---|---|
| Setup | During exposure, rats were placed in a custom-made harness; coil was placed at one hind leg from the knee to the ankle joint; the other hind leg (control) was wrapped in µ-copper foil for protection against the magnetic field |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | - | - | - | - |
No significant differences were found between exposed and non-exposed (control) bones.
The authors conclude that the results give no indications for an effect of exposure of osteoporotic and healthy rats to a 50 Hz magnetic field on bone micro-architecture and fracture healing.
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