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Medical/biological Study (experimental study)

Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice. med./biol.

By: Kitaoka K, Kitamura M, Aoi S, Shimizu N, Yoshizaki K
Published in: Bioelectromagnetics 2013; 34 (1): 43 - 51 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To study the effect of chronic extremely low frequency magnetic field exposure on emotional behavior and corticosterone synthesis in mice.
Background/further details:
5-10 mice per trial were exposed or sham exposed.

Endpoints

Exposure
General category: magnetic field, low frequency field, 50/60 Hz (AC)

Field characteristicsParameters
60 Hz
exposure duration: continuous for 8 h/day on 25 days
magnetic flux density: 3 mT

FIELD View further expo parameters

Exposed system:
animal (species/strain): mouse/ICR
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

investigated material: DNA/RNA (in vitro), blood samples
investigation on living organism
investigated organ systems: endocrine system, neuroendocrine system

time of investigation: during and after exposure

Main outcome of study (according to author)
Exposed mice showed a significant increase in total immobility time in the forced swim test and an increased latency to enter the light box in the light-dark transition test, compared with sham exposed mice. Corticosterone secretion was significantly higher in the exposed mice; however, no changes were found in the amount of the ACTH and the gene expression related to stress response. Quantification of the mRNA levels of adrenal corticosterone synthesis enzymes revealed a significant reduction in Cyp17a1 mRNA in the exposed mice.
The data suggest the possibility that high intensity and chronic exposure to extremely low frequency magnetic field induces an increase in corticosterone secretion, along with depression- and/or anxiety-like behavior, without enhancement of the hypothalamic pituitary adrenal axis.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • Kojinkai Foundation, Japan
  • Magnetic Health Science Foundation, Japan

Related articles i
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