Medical/biological Study (experimental study)
Effect of acute extremely low frequency electromagnetic field exposure on the antioxidant status and lipid levels in rat brain. med./biol. By: Martinez-Samano J, Torres-Duran PV, Juarez-Oropeza MA, Verdugo-Diaz L
Published in: Arch Med Res 2012; 43 (3): 183 - 189 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study the immediate effects of acute magnetic field exposure, immobilization, and the combination of both on the antioxidant system and lipid content in the whole brain of rat.
32 male rats were divided into four groups: 1) control group, 2) exposure group, 3) immobilization, 4) exposure + immobilization.
Immobilization was used as a positive control for physical and psychological stress.
General category: magnetic field, low frequency field, 50/60 Hz (AC)
FIELD View further expo parameters
animal (species/strain): rat/Wistar
whole body exposure
Methodsinvestigated material: tissue homogenates and supernatants; blood samples
investigated organ system: brain/CNS
time of investigation: after exposure
Main outcome of study (according to author)
Acute exposure to extremely low frequency magnetic field alone as well as "exposure + immobilization" induced a reduction in catalase and superoxide dismutase enzyme activities compared with the control group, whereas the combination of "magnetic field exposure and immobilization" also decreased both reduced glutathione (compared with the control group) and nitric oxide levels compared with the other groups. Thiobarbituric acid reactive substances in the total lipid content of the brain were higher in the "exposure + immobilization group" than in the other experimental groups. Exposure to extremely low frequency magnetic fields did not induce any changes of the stress-hormone corticosterone or triacylglycerol levels.
Acute exposure to the extremely low frequency magnetic field appears to be a mild stressor.
(Study character: medical/biological study, experimental study, full/main study)
Study funded by
- Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT), Universidad Nacional Autonoma de Mexico (UNAM), Mexico
- Universidad Nacional Autònoma de México (UNAM)
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Glossary: 50/60 Hz, AC, acute, acute exposure, animal, antioxidant, biological, blood, brain, catalase, cholesterol, CNS, colorimetry, control group, corticosterone, endocrine, endpoint, enzyme activities, exposure, extremely low frequency, full/main study, homogenates, hormone, immobilization, induced, Kits, lipid, low frequency field, magnetic field, magnetic flux density, metabolism, neurological, nitric oxide, oxidative stress, physical, plasma, positive control, psychological, rat/Wistar, rats, reactive, reduced glutathione, reduction, species, spectrophotometry, strain, stress, stressor, supernatants, superoxide dismutase, thiobarbituric acid, tissue, triacylglycerol, whole body exposure
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