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Medical/biological Study (experimental study)

The effects of long-term exposure to extremely low-frequency magnetic fields on bone formation in ovariectomized rats. med./biol.

By: Celik MS, Gur A, Akdag Z, Akpolat V, Guven K, Celik Y, Sarac AJ, Otcu S
Published in: Bioelectromagnetics 2012; 33 (7): 543 - 549 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To study the effects of 50 Hz extremely low frequency magnetic fields on rat bone metabolism.
Background/further details:
60 rats were divided into four different groups (each group n=15): 1) unexposed control group; 2) ovariectomized only; 3) non-ovariectomized, exposed; and 4) ovariectomized, exposed. Bilateral ovariectomies were performed four days before the beginning of the experiments.

Endpoint

Exposure
General category: magnetic field, low frequency field, 50/60 Hz (AC), electrotherapy

Field characteristicsParameters
50 Hz
exposure duration: continuous for 4 h/day during 6 months, starting on the fifth day after surgery
magnetic flux density: 1.5 mT

FIELD View further expo parameters

Exposed system:
animal (species/strain): rat/Sprague-Dawley
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

investigated material: blood samples
investigation on living organism
investigated organ system: muscular/skeletal system

time of investigation: before and after exposure

Main outcome of study (according to author)
Although there was no significant difference in bone mineral density values among the groups before magnetic field exposure, the bone mineral density values increased significantly after six months in the groups 3 (non-ovariectomized, exposed) and 4 (ovariectomized, exposed) and were reduced in group 2 (ovariectomized only) compared to the control group. The concentrations of bone-specific alkaline phosphatase, osteocalcin, and osteoprotogerin in the three groups also changed in a significant way compared to the control group (increase in the exposed groups 3 and 4 indicating increased osteoblast growth and activity and decrease in group 2). The N-telopeptide level decreased in the exposed groups 3 and 4 (indicating a decrease in osteoclast activity) and increased in group 2 compared with the control group.
The data suggest that osteoporosis can be inhibited by extremely low frequency magnetic fields treatments. Extremely low frequency magnetic fields may be useful in the prevention of osteoporosis in ovariectomized rats.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • Research Foundation of Dicle University, Turkey

Related articles i
Glossary: 50 Hz, AC, alkaline phosphatase, animal, bilateral, biological, blood, bone, bone mineral density, control group, DXA, electrotherapy, ELISA, endpoint, exposed, exposure, extremely low frequency, full/main study, growth, immunoassay, inhibited, low frequency field, magnetic field, magnetic flux density, metabolism, muscular, organism, Osteoblast, osteocalcin, osteoclast, osteoporosis, ovariectomized, rat/Sprague-Dawley, rats, resorption, serum, significant, skeletal, species, strain, surgery, whole body exposure

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