Medical/biological Study (experimental study)
Electric field exposure and evidence of stress in mice. med./biol. By: de Bruyn L, de Jager L
Published in: Environ Res 1994; 65 (1): 149 - 160 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To examine the effect of stress induced by an electric field in six generations of mice.
Six consecutive generations consisted of ten control pairs of adult mice and ten exposed pairs of adult mice in each generation. The examination of the adrenal glands was performed on young mice (35 days old, n=10), adults (6 months old, n=20) and old mice (18 months, n=10). Blood samples were taken from adult male mice (daytime and nighttime) as well as male and female old mice (only daytime) (n=12 in each group).
General category: electric field, 50/60 Hz (AC)
FIELD View further expo parameters
animal (species/strain): mouse/BALB/c
whole body exposure
Methodsinvestigated material: tissue slices (in vitro), blood sample
investigated organ system: endocrine system, adrenal gland
time of investigation: during and after exposure
Main outcome of study (according to author)
The mean lipid volume in the zona glomerulosa of the adrenal glands was significantly higher in the exposed adult male group than in the control group. The daytime corticosterone level of the exposed adult male mice was also significantly higher than that of the controls. The lipid profiles and corticosterone values in all other subgroups did not differ significantly.
(Study character: medical/biological study, experimental study, full/main study, blind study)Related articles
Glossary: 50/60 Hz, AC, adrenal cortex, adrenal glands, adult, animal, biological, blind study, blood, chronic, conception, control group, corticosterone, electric field, electric field strength, endocrine, endocrine system, endpoint, exposed, exposure, full/main study, hematoxylin-eosin stain, induced, in vitro, light microscopy, lipid, mean, radioimmunoassay, serum, significantly, species, strain, stress, tissue, whole body exposure
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