• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

Upregulation of specific mRNA levels in rat brain after cell phone exposure. med./biol.

PubMed Entry

Journal web site

Aim of study (according to editor)
To check the hypothesis that cell phone irradiation can cause cellular damage to the rat brain leading to increased mRNA transcription of injury-associated proteins.
Background/further details:
Fourteen 3-month-old male adult rats, weighing 250 to 350 g, were used.

Endpoint

• molecular biosynthesis: mRNA synthesis of several injury-associated proteins

Exposure
General category: analog mobile phone, digital mobile phone, PCS, CDMA, microwaves

Field characteristics	Parameters
1.9 GHz exposure duration: repeated daily exposure, 2 x 3 h/day, for 18 weeks	SAR: 1.8 W/kg (AMPS) SAR: 0.9 W/kg (CELL) SAR: 1.18 W/kg (PCS)

Exposed system:
animal (species/strain): rat/Sprague-Dawley
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

• molecular biosynthesis: mRNA synthesis of several injury-associated proteins: calcium-ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor (reverse transcriptase polymerase chain reaction)
• others: temperature of the face surface nearest the phone and rectal temperature at the end of exposure (thermometer)

Main outcome of study (according to author)
A statistically significant mRNA up-regulation of all investigated injury-associated proteins in the brains of rats exposed to cell phone irradiation was found. The differences in temperature measured were not statistically sinificant.
The authors conclude that relative chronic exposure to cell phone microwave irradiation may result in cumulative injuries that could eventually lead to clinically significant neurological damage.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

• not stated

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