Epidemiological Study (cohort study)
Use of mobile phones and risk of brain tumours: update of Danish cohort study. epidemiol. By: Frei P, Poulsen AH, Johansen C, Olsen JH, Steding-Jessen M, Schüz J
Published in: BMJ 2011; 343 : d6387 ( full article, PubMed Entry , Journal web site )
Aim of study (according to author)
A follow-up of a nationwide cohort was performed to investigate the risk of brain tumors among Danish mobile telephone subscribers from 1990 through 2007.
Further results of this Danish cohort study are published in Johansen et al (2001), Schüz et al (2006), and Schüz et al (2011).
To obtain information on highest attained education and disposable income, the data were linked to a cohort study on social inequality and cancer.
Endpoints/type of risk estimationEstimate of incidence by incidence rate ratio
groups of exposure:
- mobile phone
- assessment by list (mobile phone subscribers of two Danish network operators 1987 - 1995)
|Reference group 1: || non-subscribers |
|group 2: || subscribers |
|group 3: || subscribers: 1 - 4 years of subscription |
|group 4: || subscribers: 5 - 9 years of subscription |
|group 5: || subscribers: ≥ 10 years of subscription |
|group 6: || subscribers: 10 - 12 years of subscription |
|group 7: || subscribers: ≥ 13 years of subscription |
Study group: men and women, aged over 30 years
Group characteristics: Danes born after 1925 in Denmark
Observation period: 1990 - 2007
Study location: Denmark
Source of data: Danish Cancer Registry
Exclusion criteria: corporate customers, no permanent residence in Denmark
Remark: 3.8 million person years, male subscribers providing 3.2 million person years
|Study size || cohort |
|number total ||358,403|
Statistical analysis using Poisson regression model (adjusted for age, education, calendar period, disposable income)
Results/conclusion (according to author)
No overall increased risk of brain tumors or for all cancers combined associated with use of mobile phones was observed. No dose-response relation was found with regard to years of subscription or to the anatomical site of the glioma.
The authors concluded that in this update of a large nationwide cohort study of mobile phone use, there was no increased risk of brain tumors, providing little evidence for a causal association.
Limitations (according to author): The authors noted that a limitation of the study is potential misclassification of exposure. No information on the actual amount of mobile phone use was available.
(Study character: epidemiological study, cohort study)
Study funded by
Published comments on this article:Related articles
- Danish Graduate School Network in Public Health Science (GRASPH), Denmark
- Danish Strategic Research Council, Denmark
- Swiss National Science Foundation (SNF)
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Glossary: anatomical, brain tumors, cancer registry, cancers, cohort, cohort study, dose-response relation, epidemiological, evidence, exposure, follow-up, glioma, incidence, meningioma, mobile phone, person years, potential, risk, statistical
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