Medical/biological Study (experimental study)
Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: Influence of cell cycle. med./biol. By: Sannino A, Zeni O, Sarti M, Romeo S, Reddy SB, Belisario MA, Prihoda TJ, Vijayalaxmi, Scarfi MR
Published in: Int J Radiat Biol 2011; 87 (9): 993 - 999 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study the influence of the cell cycle on the adaptive response induced by the exposure of human blood lymphocytes to radiofrequency fields.
Adaptive response: Different cell types that were exposed to an extremely small adaptation dose of a genotoxic agent were found to be less susceptible to the induction of genetic damage when given a higher challenge dose of the same or similar genotoxic agent. The induction of an adaptive response
was shown to be influenced by several factors (e.g. the dose used for adaptation, the dose rate, the time between the adaptation and
Human peripheral blood lymphocytes in G0 phase, G1 phase or S phase of the cell cycle were exposed for 20 hours to an adaptive dose of 900 MHz radiofrequency and then treated with a challenge dose of 100 ng/ml mitomycin C.
Lymphocytes of nine different healthy male donors were investigated.
General category: mobile communication system, mobile phone, GSM, radio frequency field
| 900 MHz |
exposure duration: continuous for 20 h
|SAR: 1.25 W/kg average over time|
SAR: 10 W/kg peak value
FIELD View further expo parameters
intact cell/cell culture (in vitro)
Methodsinvestigated material: intact cell/cell culture (in vitro), chromosomes
time of investigation: after exposure
Main outcome of study (according to author)
The data indicated that the cells which were exposed to an adaptive dose of radiofrequency in G0 phase and G1 phase of the cell cycle did not exhibit an adaptive response while such a response was observed when the cells were exposed to an adaptive dose of radiofrequency in the S phase of the cell cycle.
These findings confirmed the observations reported in previous investigations (Sannino et al. 2009) where an adaptive response was found in human blood lymphocytes exposed to an adaptive dose of radiofrequency in S phase of the cell cycle and further suggested that the timing of an adaptive dose exposure of radiofrequency is important to elicit an adaptive response.
(Study character: medical/biological study, experimental study, full/main study)
Study funded byRelated articles
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Glossary: adaptive, binucleate, biological, blood, cell culture, cell cycle, cell division, cells, cell viability, chromosomes, cytokinesis block micronucleus assay, cytotoxicity, DNA, donors, dose, dose rate, endpoint, exposed, exposure, full/main study, G0 phase, G1 phase, genetic, genotoxicity, Giemsa stain, GSM, healthy, human, induction, in vitro, light microscopy, lymphocytes, MHz, Micronucleus, Mitomycin C, mobile communication, mobile phone, mutation, Nuclei, peripheral, proliferation, proliferation index, radiofrequency, SAR, S phase
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