Medical/biological Study (experimental study)
Spindle disturbances in human-hamster hybrid (A(L)) cells induced by the electrical component of the mobile communication frequency range signal. med./biol. By: Schrader T, Kleine-Ostmann T, Münter K, Jastrow C, Schmid E
Published in: Bioelectromagnetics 2011; 32 (4): 291 - 301 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study whether either the electrical (E field) and/or the magnetic field (H field) component of an electromagnetic field at 900 MHz can be associated with the effectiveness of the spindle-disturbing potential (as shown in a previous study, see Schrader et al. 2008).
Three experiments were performed: Two experiments were performed at room temperature (20-22°C) and a third experiment at 37°C.
General category: mobile communication system, mobile phone, GSM, radio frequency field, electric field, magnetic field
| 900 MHz |
exposure duration: continuous for 0.5 h
|power: 200 mW effective value|
SAR: 10.7 mW/kg min value (calculated 0.1 mm above and in the center of the slide)
SAR: 17.2 mW/kg max value (calculated 0.1 mm above and in the center of the slide)
FIELD View further expo parameters
intact cell/cell culture (in vitro)
FC2 cells (human-hamster hybrid (AL)) cells
Methodsinvestigated material: intact cell/cell culture (in vitro), chromosomes
time of investigation: after exposure
Main outcome of study (according to author)
The data showed that only cells exposed to the magnetic field component of the electromagnetic field were not different from the control. The results have confirmed the spindle-acting potential of a radiofrequency exposure at 835 MHz in human-hamster hybrid cells, which was reported for a 0.5 h exposure at field strengths from 45 to 90 V/m (see Schrader et al. 2008 and Schmid and Schrader 2007). Moreover, both the earlier and present data sets
have shown that the fractions of anaphases and telophases with spindle disturbances are twice as high at 90 V/m than at 45 V/m. The findings were independent of the exposure temperatures at room temperature or
The data indicate that an exposure of cells to an electromagnetic field at electric field strengths of 45 and 90 V/m, as well as to the separated E component of the electromagnetic field, induce significant spindle disturbances in anaphases and telophases of the cell cycle.
(Study character: medical/biological study, experimental study, full/main study)
Study funded byRelated articles
Glossary: aceto-orcein stain, anaphases, biological, cell culture, cell cycle, cell division, cells, cell viability, chromosomes, effective value, electrical, electric field, electric field strengths, electromagnetic field, endpoint, exposed, exposure, field strengths, full/main study, genotoxicity, GSM, H field, human, hybrid, in vitro, magnetic field, metaphases, MHz, mitotic index, mobile communication, mobile phone, mutation, potential, power, proliferation, radiofrequency, SAR, significant, spindle, telophases
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