Medical/biological Study (experimental study)
The effect of long-term extremely low-frequency magnetic field on geometric and biomechanical properties of rats' bone. med./biol. By: Akdag MZ, Dasdag S, Erdal N, Buyukbayram H, Gurgul S
Published in: Electromagn Biol Med 2010; 29 (1-2): 9 - 18 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study the possible effects of extremely low frequency magnetic field on geometric and biomechanical properties of rats' bone.
30 male rats were divided into three groups: sham exposure group (n=10) and two exposure groups (n=20)
- geometric and biomechanical properties of bone
General category: magnetic field, low frequency field, 50/60 Hz (AC)
FIELD View further expo parameters
animal (species/strain): rat/Sprague-Dawley
whole body exposure
investigated material: tissue slices (in vitro), femur and femur homogenates
- geometric and biomechanical properties of bone: tensile test (to measure e.g. tensile strength, energy absoption capacity, toughness); cortical bone thickness (hematoxylin-eosin stain, light microscopy); cross-sectional area of the femoral shaft; femur length
investigated organ system: muscular/skeletal system
time of investigation: after exposure
Main outcome of study (according to author)
The data showed a significant decrease of cross-sectional area of the femoral shaft in rats exposed to a 100 µT magnetic field in comparison to sham exposed and 500 µT exposed rats. Maximum load (i.e. strength) increased in 100 µT and 500 µT exposed rats when compared to that of the sham exposed rats. The cortical thickness of the femurs of exposed rats (100 µT and 500 µT) was significantly decreased in comparison to that of the sham exposure group.
However, no significant differences were found in the other biomechanical parameters between the groups, such as e.g. length of the femur, energy absorption capacity, toughness of bone.
These experiments demonstrated that 100 µT and 500 µT magnetic fields could affect biomechanical and geometrical properties of rats' bone.
(Study character: medical/biological study, experimental study, full/main study, blind study)
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Glossary: 50/60 Hz, absorption, AC, animal, biological, blind study, bone, cortical, endpoint, exposed, exposure, extremely low frequency, femur, full/main study, hematoxylin-eosin stain, homogenates, in vitro, light microscopy, low frequency field, magnetic field, magnetic flux density, muscular, rat/Sprague-Dawley, rats, sham exposed, significant, skeletal, species, strain, tissue, whole body exposure
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