Medical/biological Study (experimental study)
Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain. med./biol. By: Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taskin A
Published in: Biol Trace Elem Res 2010; 138 (1-3): 238 - 249 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study the effects of 100 µT and 500 µT extremely low frequency magnetic fields, which are the limit values for public environmental and occupational magnetic field exposure, on apoptosis and oxidative stress values in the brains of rats (each group n=10).
General category: magnetic field, low frequency field, 50/60 Hz (AC)
FIELD View further expo parameters
animal (species/strain): rat/Sprague-Dawley
whole body exposure
Methodsinvestigated material: tissue slices (in vitro), tissue homogenates and supernatants
investigated organ system: brain/CNS
time of investigation: after exposure
Main outcome of study (according to author)
Apoptosis and myeloperoxidase
enzyme activity were not significantly different between the groups. Catalase enzyme activity decreased in both exposure groups, while total antioxidant capacity was lower in the 500 µT exposed group than those in the 100 µT and the sham exposure groups. Malondialdehyde, total oxidant status, and oxidative stress index values were found to be higher in the 500 µT group than those in the 100 µT and the sham exposure groups.
The authors conclude, that apoptosis was not changed by long-term extremely low frequency magnetic field exposure, while both 100 µT and 500 µT extremely low frequency magnetic field exposure induced a toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense system.
(Study character: medical/biological study, experimental study, full/main study, blind study)
Study funded byRelated articles
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Glossary: 50/60 Hz, AC, animal, antioxidant, apoptosis, biological, blind study, brain, caspase, catalase, CNS, endpoint, enzyme activity, exposed, exposure, extremely low frequency, full/main study, homogenates, induced, in vitro, limit values, lipid peroxidation, low frequency field, magnetic field, magnetic flux density, malondialdehyde, myeloperoxidase, neurological, occupational exposure, oxidant, oxidative stress, rat, rat/Sprague-Dawley, sham exposure, significantly, species, spectrophotometry, strain, supernatants, tissue, toxic, whole body exposure
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