Medical/biological Study (experimental study)
The protective effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on electric field-induced hepatic oxidative stress. med./biol. By: Güler G, Turkozer Z, Tomruk A, Seyhan N
Published in: Int J Radiat Biol 2008; 84 (8): 669 - 680 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To examine the effects of extremely low frequency electric fields on oxidative stress, nitrosative stress parameters and antioxidant enzyme activities in the liver tissue of guinea pigs. The study also adresses whether individual and combined application of N-acetyl-L-cysteine and epigallocatechin-3-gallate decreases the harmful effects of extremely low frequency electric fields.
80 male guina pigs were randomly divided into eight groups (10 each): 1) sham exposure group, 2) N-acetyl-L-cysteine group (NAC), 3) epigallocatechin-3-gallate group (EGCG), 4) NAC + EGCG group, 5) electric field exposure group, 6) NAC + electric field exposure group, 7) EGCG + electric field group, and 8) NAC + EGCG + electric field group. All exposures started at 09:00 h and ended at 17:00 h for seven consecutive days.
General category: electric field, low frequency field, 50/60 Hz (AC), power transmission line
FIELD View further expo parameters
animal (species/strain): guinea pig
whole body exposure
Methodsinvestigated material: tissue homogenates/supernatants
organ system(s): liver
time of investigation: after exposure
Main outcome of study (according to author)
The results indicated a significant increase in the levels of oxidant products (malondialdehyde, nitrate, nitrite, total level of nitric oxide), and a significant decrease in antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, myeloperoxidase). The individual or combined application of N-acetyl-L-cysteine and epigallocatechin-3-gallate prior to electric field application resulted in the reduction of oxidative stress.
Taken together, these findings support the suggestion that N-acetyl-L-cysteine and epigallocatechin-3-gallate might have hepato-protective effects in extremely low frequency electric field induced oxidative and nitrosative stress.
(Study character: medical/biological study, experimental study, full/main study)
Study funded by
- Gazi University Research Foundation, Turkey
- Martinez-Samano J et al. (2010): Effects of acute electromagnetic field exposure and movement restraint on...
- Polaniak R et al. (2010): Influence of an Extremely Low Frequency Magnetic Field (ELF-EMF) on...
- Ozgur E et al. (2010): Mobile phone radiation-induced free radical damage in the liver is inhibited by...
- Coskun S et al. (2009): Effects of continuous and intermittent magnetic fields on oxidative parameters...
- Güler G et al. (2009): Protein oxidation under extremely low frequency electric field in guinea pigs....
- Güler G et al. (2009): Antioxidants alleviate electric field-induced effects on lung tissue based on...
- Turkozer Z et al. (2008): Effects of exposure to 50 Hz electric field at different strengths on oxidative...
- Canseven AG et al. (2008): Effects of various extremely low frequency magnetic fields on the free radical...
- Akdag Z et al. (2007): Alteration of nitric oxide production in rats exposed to a prolonged, extremely...
- Güler G et al. (2007): Electric field effects on Guinea pig serum: the role of free radicals.
- Seyhan N et al. (2006): In vivo effects of ELF MFs on collagen synthesis, free radical processes,...
- Güler G et al. (2006): Effects of static and 50 Hz alternating electric fields on superoxide dismutase...
- Harakawa S et al. (2005): Effects of a 50 Hz electric field on plasma lipid peroxide level and...
- Zwirska-Korczala K et al. (2004): Influence of extremely-low-frequency magnetic field on antioxidative melatonin...
- Simko M et al. (2001): Stimulation of phagocytosis and free radical production in murine macrophages...
- Yoshikawa T et al. (2000): Enhancement of nitric oxide generation by low frequency electromagnetic field.
- Kula B et al. (2000): Effects of static and ELF magnetic fields on free-radical processes in rat...
- Brocklehurst B et al. (1996): Free radical mechanism for the effects of environmental electromagnetic fields...
Glossary: 50/60 Hz, AC, animal, antioxidant, biological, cell, electric field, electric field strength, endpoint, enzyme activities, exposure, extremely low frequency, full/main study, glutathione peroxidase, hepato, homogenates, induced, lipid peroxidation, low frequency field, malondialdehyde, myeloperoxidase, N-acetyl-L-cysteine, nitrate, nitric oxide, nitrite, nitrosative stress, oxidant, oxidative, oxidative stress, power transmission line, randomly, reduction, sham exposure, significant, species, spectrophotometry, strain, supernatants, superoxide dismutase, tissue, whole body exposure
© 1997 - 2013, Research Center for Bioelectromagnetic Interaction (femu - RWTH Aachen University, Germany).
The informational contents of the EMF-Portal are available free of charge for personal and strictly non-commercial purposes. The informational contents of the EMF-Portal may be retrieved, read or printed, but not (i) copied, (ii) changed or (iii) saved in any format, neither electronically nor on other storage media. Permissions for publication, reproduction, commercial purposes or third party propagation of contents of the EMF-Portal – including partial excerpts or revised formats – have to be obtained from the femu Aachen University-copyright holders. By retrieving, reading or printing these documents you expressly state your agreement with all conditions in the fine print.