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Medical/biological Study (experimental study)

The protective effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on electric field-induced hepatic oxidative stress. med./biol.

By: Güler G, Turkozer Z, Tomruk A, Seyhan N
Published in: Int J Radiat Biol 2008; 84 (8): 669 - 680 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To examine the effects of extremely low frequency electric fields on oxidative stress, nitrosative stress parameters and antioxidant enzyme activities in the liver tissue of guinea pigs. The study also adresses whether individual and combined application of N-acetyl-L-cysteine and epigallocatechin-3-gallate decreases the harmful effects of extremely low frequency electric fields.
Background/further details:
80 male guina pigs were randomly divided into eight groups (10 each): 1) sham exposure group, 2) N-acetyl-L-cysteine group (NAC), 3) epigallocatechin-3-gallate group (EGCG), 4) NAC + EGCG group, 5) electric field exposure group, 6) NAC + electric field exposure group, 7) EGCG + electric field group, and 8) NAC + EGCG + electric field group. All exposures started at 09:00 h and ended at 17:00 h for seven consecutive days.

Endpoint

Exposure
General category: electric field, low frequency field, 50/60 Hz (AC), power transmission line

Field characteristicsParameters
50 Hz
exposure duration: 8 h/d for 7 days
electric field strength: 12 kV/m

FIELD View further expo parameters

Exposed system:
animal (species/strain): guinea pig
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

investigated material: tissue homogenates/supernatants
organ system(s): liver

time of investigation: after exposure

Main outcome of study (according to author)
The results indicated a significant increase in the levels of oxidant products (malondialdehyde, nitrate, nitrite, total level of nitric oxide), and a significant decrease in antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, myeloperoxidase). The individual or combined application of N-acetyl-L-cysteine and epigallocatechin-3-gallate prior to electric field application resulted in the reduction of oxidative stress.
Taken together, these findings support the suggestion that N-acetyl-L-cysteine and epigallocatechin-3-gallate might have hepato-protective effects in extremely low frequency electric field induced oxidative and nitrosative stress.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • Gazi University Research Foundation, Turkey

Related articles i
Glossary: 50/60 Hz, AC, animal, antioxidant, biological, cell, electric field, electric field strength, endpoint, enzyme activities, exposure, extremely low frequency, full/main study, glutathione peroxidase, hepato, homogenates, induced, lipid peroxidation, low frequency field, malondialdehyde, myeloperoxidase, N-acetyl-L-cysteine, nitrate, nitric oxide, nitrite, nitrosative stress, oxidant, oxidative, oxidative stress, power transmission line, randomly, reduction, sham exposure, significant, species, spectrophotometry, strain, supernatants, superoxide dismutase, tissue, whole body exposure

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