Medical/biological Study (experimental study)
Effects of Long-term Exposure of Extremely Low Frequency Magnetic Field on Oxidative/Nitrosative Stress in Rat Liver. med./biol. By: Erdal N, Gurgul S, Tamer L, Ayaz L
Published in: J Radiat Res 2008; 49 (2): 181 - 187 ( full article, PubMed Entry , Journal web site )
Aim of study (according to author)
This study was performed to examine the long-term effects of 50 Hz, 1 mT magnetic field on oxidative stress and nitrosative stress in liver tissues of rats.
Altogether thirty-two (16 male, 181 +/- 10 g body weight and 16 female, 178 +/- 15 g body weight ), eight week-old rats were used.
General category: magnetic field, 50/60 Hz (AC)
| 50 Hz |
exposure duration: continuous for 4 h/day on 45 days
|magnetic flux density: 1 mT (+/- 0.05 mT)|
FIELD View further expo parameters
animal (species/strain): rat/Wistar albino
whole body exposure
Methodsinvestigated material: isolated bio./chem. substance (in vitro), tissue homogenate
organ system(s): liver
time of investigation: after exposure
Main outcome of study (according to author)
Concerning malondialdehyde levels, there were no significant differences between the control groups and magnetic field exposure groups. However, female rats exposed to magnetic field showed significantly increased nitrotyrosine levels. This effect was not seen in exposed male rats.
These results suggest that the long-term extremely low frequency magnetic field exposure may enhance the oxidative/nitrosative stress in liver tissue of the female rats and could have a negative effect on cellular proteins rather than lipids by enhancing nitrotyrosine formation.
(Study character: medical/biological study, experimental study, full/main study)
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Glossary: 50 Hz, AC, animal, biological, cell, cellular, control groups, endpoint, exposed, exposure, extremely low frequency, full/main study, high performance liquid chromatography, homogenate, in vitro, lipids, liver, magnetic field, magnetic flux density, malondialdehyde, nitrogen, nitrosative stress, nitrotyrosine, oxidative, oxidative stress, oxygen, Proteins, rat/Wistar, rats, significant, species, strain, stress, thiobarbituric acid, tissue, whole body exposure
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