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Medical/biological Study (experimental study)

Effects of Long-term Exposure of Extremely Low Frequency Magnetic Field on Oxidative/Nitrosative Stress in Rat Liver. med./biol.

By: Erdal N, Gurgul S, Tamer L, Ayaz L
Published in: J Radiat Res 2008; 49 (2): 181 - 187 ( open external web page full article, open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
This study was performed to examine the long-term effects of 50 Hz, 1 mT magnetic field on oxidative stress and nitrosative stress in liver tissues of rats.
Background/further details:
Altogether thirty-two (16 male, 181 +/- 10 g body weight and 16 female, 178 +/- 15 g body weight ), eight week-old rats were used.

Endpoint

Exposure
General category: magnetic field, 50/60 Hz (AC)

Field characteristicsParameters
50 Hz
exposure duration: continuous for 4 h/day on 45 days
magnetic flux density: 1 mT (+/- 0.05 mT)

FIELD View further expo parameters

Exposed system:
animal (species/strain): rat/Wistar albino
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

investigated material: isolated bio./chem. substance (in vitro), tissue homogenate
organ system(s): liver

time of investigation: after exposure

Main outcome of study (according to author)
Concerning malondialdehyde levels, there were no significant differences between the control groups and magnetic field exposure groups. However, female rats exposed to magnetic field showed significantly increased nitrotyrosine levels. This effect was not seen in exposed male rats.
These results suggest that the long-term extremely low frequency magnetic field exposure may enhance the oxidative/nitrosative stress in liver tissue of the female rats and could have a negative effect on cellular proteins rather than lipids by enhancing nitrotyrosine formation.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • not stated/none

Related articles i
Glossary: 50 Hz, AC, animal, biological, cell, cellular, control groups, endpoint, exposed, exposure, extremely low frequency, full/main study, high performance liquid chromatography, homogenate, in vitro, lipids, liver, magnetic field, magnetic flux density, malondialdehyde, nitrogen, nitrosative stress, nitrotyrosine, oxidative, oxidative stress, oxygen, Proteins, rat/Wistar, rats, significant, species, strain, stress, thiobarbituric acid, tissue, whole body exposure

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