• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

Lymphomas in Eµ-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields. med./biol.

PubMed Entry

Journal web site

Aim of study (according to author)
To determine whether long-term exposure to pulse-modulated radiofrequency fields similar to those used in digital mobile telecommunications would increase the incidence of lymphoma in Eµ-Pim1 transgenic mice (expressing an activated Pim1 oncogene in their lymphoid cells).

Endpoint

• cancer: lymphoma

Exposure
General category: digital mobile phone, GSM

Field characteristics	Parameters
900 MHz pulsed (PW) exposure duration: repeated daily exposure for 30 min every 12 h for up to 18 months	power: 9.1 W mean value SAR: 4.2 W/kg average over mass (whole body) (0.008-4.2 W/kg for an individual mouse) SAR: 1.4 W/kg average over mass (whole body) (0.13-1.4 W/kg for groups of five mice) power flux density: 13 W/m² max value (2.6 - 13 W/m²)

Exposed system:
animal (species/strain): mouse/Eµ-Pim1 transgenic (ppG64) and nontransgenic C57BL/6NTac
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

• cancer: lymphoblastic and non-lymphoblastic lymphoma (lymphoma occurence and time to occurence; determination of the cell lineage, see below)
• morphological/histopathological changes: histopathological tumor classification
• others: renal diseases; body weight

Main outcome of study (according to author)
Lymphoma risk was found to be significantly higher in the exposed mice than in the controls.

(Study character: medical/biological study, experimental study, full/main study, single-blind study)

Study funded by

• National Health and Medical Research Council (NHMRC), Australia
• Telstra Research Laboratories (TRL), Australia

• Utteridge TD et al. (2002): Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does...
• Oberto G et al. (2007): Carcinogenicity Study of 217 Hz Pulsed 900 MHz Electromagnetic Fields in Pim1...

• by  Goldstein LS, Kheifets L, van Deventer E, Repacholi M
• by  SSK
• by  Lin JC

• Smith P et al. (2007): GSM and DCS Wireless Communication Signals: Combined Chronic...
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