Medical/biological Study (experimental study)
Potential Impact of Simulated Mobile Phone Radiation on Blood-Brain Barrier. med./biol. By: Vojtisek M, Knotkova J, Kasparova L, Hornychova M, Frantik M, Svandova E
Published in: Electromagn Biol Med 2005; 24 (3): 355 - 358 ( Journal web site )
Aim of study (according to author)
1) To study brain manganese (Mn) levels in rats with or without experimental manganese administration (2.88 mg Mn2+, applied at the start of the experiment) and with or without the exposure to electromagnetic field at the end of acute or longterm exposures.
2) To observe rats behaviour at the end of longterm exposures (after 12 weeks) with possible implication to manganese or electromagnetic field exposure.
Manganese has a neurotoxic potential as a result of professional (metalurgy) and nonprofessional (traffic) exposure, when in excess in the brain.
General category: mobile phone
FIELD View further expo parameters
animal (species/strain): rat/Wistar
partial body exposure: head
investigated material: brain tissue
- effects on the neurological system: blood-brain barrier permeability (Mn in the brains; atomic spectrometry)
- cognitive/behavioral endpoints: not further specified neurobehavioural tests (to test active and passive emotional reaction, activation, exploratory activity, spontaneous motoric activity)
investigation on living organism
investigated organ system: brain/CNS
time of investigation: after exposure
Main outcome of study (according to author)
In acute test, significant increase in brain manganese level was found in rats exposed to both factors (electromagnetic fields and manganese) as compared to Mn administration only.
Within subchronic test such interaction did not appear, but in vivo observation of exposed rats (exposure to Mn and/or electromagnetic field) at the end of the test have demonstrated signficant behavioral changes as compared to unexposed animals.
(Study character: medical/biological study, experimental study, full/main study)
Study funded by
- MSMT (Ministry of Education, Youth and Sports) - COST, Czech Republic
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Glossary: acute, acute exposure, animals, behavioral, biological, blood-brain barrier, brain, CNS, cognitive, electromagnetic field, emotional, endpoint, exposed, exposure, full/main study, in vivo, Mn, mobile phone, neurological, neurotoxic, organism, partial body exposure, permeability, potential, power, rat/Wistar, rats, significant, species, spectrometry, strain, subchronic, tissue
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