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Medical/biological Study (experimental study)

Potential Impact of Simulated Mobile Phone Radiation on Blood-Brain Barrier. med./biol.

By: Vojtisek M, Knotkova J, Kasparova L, Hornychova M, Frantik M, Svandova E
Published in: Electromagn Biol Med 2005; 24 (3): 355 - 358 ( open external web page Journal web site )

Aim of study (according to author)
1) To study brain manganese (Mn) levels in rats with or without experimental manganese administration (2.88 mg Mn2+, applied at the start of the experiment) and with or without the exposure to electromagnetic field at the end of acute or longterm exposures.
2) To observe rats behaviour at the end of longterm exposures (after 12 weeks) with possible implication to manganese or electromagnetic field exposure.
Background/further details:
Manganese has a neurotoxic potential as a result of professional (metalurgy) and nonprofessional (traffic) exposure, when in excess in the brain.

Endpoint

Exposure
General category: mobile phone

Field characteristicsParameters
field 1: 900 MHz
exposure duration: continuous for 30 min

acute exposure		power: 1 W
field 2: 900 MHz
exposure duration: repeated daily exposure, 30 min/day for 6 or 12 weeks

subchronic exposure		power: 1 W

FIELD View further expo parameters

Exposed system:
animal (species/strain): rat/Wistar
partial body exposure: head

Methods
Endpoint/Measurement parameters/Methodology

investigated material: brain tissue
investigation on living organism
investigated organ system: brain/CNS

time of investigation: after exposure

Main outcome of study (according to author)
In acute test, significant increase in brain manganese level was found in rats exposed to both factors (electromagnetic fields and manganese) as compared to Mn administration only.
Within subchronic test such interaction did not appear, but in vivo observation of exposed rats (exposure to Mn and/or electromagnetic field) at the end of the test have demonstrated signficant behavioral changes as compared to unexposed animals.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • MSMT (Ministry of Education, Youth and Sports) - COST, Czech Republic

Related articles i
Glossary: acute, acute exposure, animals, behavioral, biological, blood-brain barrier, brain, CNS, cognitive, electromagnetic field, emotional, endpoint, exposed, exposure, full/main study, in vivo, Mn, mobile phone, neurological, neurotoxic, organism, partial body exposure, permeability, potential, power, rat/Wistar, rats, significant, species, spectrometry, strain, subchronic, tissue

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