Medical/biological Study (experimental study)

Effects of static and ELF magnetic fields on free-radical processes in rat liver and kidney med./biol.

Journal web site

Aim of study (according to author)
To study the activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase and the levels of malondialdehyde in the liver and kidneys of male and female rats (n=40) exposed to static magnetic fields and extremely low frequency magnetic fields.

Endpoints

• molecular biosynthesis: malondialdehyde content
• cell function: antioxidant enzyme activity in kidney and liver tissue

Exposure
General category: magnetic field, static magnetic field, low frequency field, 50/60 Hz (AC)

Field characteristics	Parameters
field 1: DC/static exposure duration: 2 h/day for 20 days	magnetic flux density: 0.49 T (non-linear MF with 0-2 T/m gradient)
field 2: 50 Hz exposure duration: 2 h/day for 20 days	magnetic flux density: 0.018 T

Exposed system:
animal (species/strain): rat/Wistar
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

• molecular biosynthesis: malondialdehyde content in kidney and liver tissue
• cell function: antioxidant enzyme activity in kidney and liver tissue

Main outcome of study (according to author)
Extremely low frequency magnetic fields increased all enzyme activities and malondialdehyde levels in both the liver and kidneys. In contrast, static magnetic field did not produce changes.
The data indicate that extremely low frequency magnetic fields affect free radical processes in the liver and kidney.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

• not stated/none

• Emre M et al. (2011): Oxidative stress and apoptosis in relation to exposure to magnetic field.
• Gholampour F et al. (2011): Chronic Exposure to Extremely Low Frequency Electromagnetic Field Induces Mild...
• Akdag MZ et al. (2010): Effects of extremely low-frequency magnetic field on caspase activities and...
• Sharifian A et al. (2009): Effect of extremely low frequency magnetic field on antioxidant activity in...
• Erdal N et al. (2008): Effects of Long-term Exposure of Extremely Low Frequency Magnetic Field on...
• Güler G et al. (2008): The protective effects of N-acetyl-L-cysteine and Epigallocatechin-3-gallate on...
• Turkozer Z et al. (2008): Effects of exposure to 50 Hz electric field at different strengths on oxidative...
• Eraslan G et al. (2007): Studies on antioxidant enzymes in mice exposed to pulsed electromagnetic...
• Tohumoglu G et al. (2007): Formulation of ELF magnetic fields' effects on malondialdehyde level and...
• Seyhan N et al. (2006): In vivo effects of ELF MFs on collagen synthesis, free radical processes,...
• Akdag Z et al. (2006): Effect of ELF magnetic fields on lipid peroxidation, sperm count, p53, and...
• Bediz CS et al. (2006): Zinc supplementation ameliorates electromagnetic field-induced lipid...
• Jelenkovic A et al. (2006): Effects of extremely low-frequency magnetic field in the brain of rats.
• Güler G et al. (2006): Effects of static and 50 Hz alternating electric fields on superoxide dismutase...
• Jelenkovic A et al. (2005): The effects of exposure to extremely low-frequency magnetic field and...
• Harakawa S et al. (2005): Effects of a 50 Hz electric field on plasma lipid peroxide level and...
• Lee BC et al. (2004): Effects of extremely low frequency magnetic field on the antioxidant defense...
• Kula B et al. (2002): A study of the effects of static and extremely low frequency magnetic fields on...
• Sobczak A et al. (2002): Effects of Electromagnetic Field on Free-Radical Processes in Steelworkers....
• Kula B et al. (1996): A study of magnetic field effects on fibroblast cultures. Part 2. The...