Medical/biological Study (experimental study)
DNA strand breaks are not induced in human cells exposed to 2.1425 GHz band CW and W-CDMA modulated radiofrequency fields allocated to mobile radio base stations. med./biol. By: Sakuma N, Komatsubara Y, Takeda H, Hirose H, Sekijima M, Nojima T, Miyakoshi J
Published in: Bioelectromagnetics 2006; 27 (1): 51 - 57 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To conduct a large-scale in vitro study focused on the effects of low level radiofrequency fields from mobile radio base stations employing the International Mobile Telecommunications-2000 (IMT-2000) cellular system in order to test the hypothesis that modulated radiofrequency fields may act as a DNA damaging agent.
First, the responses of human cells to microwave exposure at a specific absorption rate (SAR) of 80 mW/kg, which corresponds to the limit of the average whole body SAR for general public exposure defined as a basic restriction in the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines were evaluated.
Second, it was investigated whether continuous wave and Wideband Code Division Multiple Access (W-CDMA) modulated signal radiofrequency fields at 2.1425 GHz induced different levels of DNA damage.
General category: mobile communication system, UMTS
FIELD View further expo parameters
intact cell/cell culture (in vitro)
A172 (human glioblastoma cells) and IMR90 fibroblasts (from fetal lungs)
Methodsinvestigated material: DNA/RNA (in vitro), intact cell/cell culture (in vitro)
time of investigation: after exposure
Main outcome of study (according to author)
Under the same radiofrequency field exposure conditions, no significant differences in the DNA strand breaks were found between the test groups exposed to W-CDMA or continuous wave irradiation and the sham exposed negative controls. The data confirm that low level exposures do not act as a genotoxicant up to a SAR of 800 mW/kg.
(Study character: medical/biological study, experimental study, full/main study, blind study)
Study funded byRelated articles
Glossary: alkaline, base stations, biological, blind study, cell, cell culture, cellular, Comet Assays, continuous wave, DNA, DNA strand breaks, endpoint, exposed, exposure, fetal, fibroblasts, full/main study, genotoxicity, GHz, glioblastoma, human, hypothesis, ICNIRP, IMT-2000, induced, in vitro, irradiation, lungs, mean value, microwave, mobile communication, mobile radio, modulated, mutation, negative controls, pulsed, PW, radiofrequency, restriction, RNA, SAR, sham exposed, signal, significant, UMTS, W-CDMA
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