Medical/biological Study (experimental study)
Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. med./biol. By: Kuribayashi M, Wang J, Fujiwara O, Doi Y, Nabae K, Tamano S, Ogiso T, Asamoto M, Shirai T
Published in: Bioelectromagnetics 2005; 26 (7): 578 - 588 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To study whether electromagnetic field exposure causes any damage of blood-brain barrier in rats with ages equivalent to the time of blood-brain barrier genesis and the young adult.
Immature (4 weeks old) and young (10 weeks old) rats were used.
General category: mobile communication system, PDC, TDMA
| 1439 MHz |
exposure duration: repeated daily exposure, 90 min/day, 6 days/week, for 1 or 2 weeks
|SAR: 2 W/kg average over mass (brain)|
SAR: 6 W/kg average over mass (brain)
SAR: 0.29 W/kg max value (whole body)
FIELD View further expo parameters
animal (species/strain): rat/Fischer 344
partial body exposure: head (nose)
Methodsinvestigated material: isolated bio./chem. substance (in vitro), DNA/RNA (in vitro), tissue slices (in vitro), isolated organ (in vitro)
investigation on living organism
investigated organ system: brain/CNS, liver, kidneys
time of investigation: during and after exposure
Main outcome of study (according to author)
Although expression of the three genes was decreased after administration of 1,3-dinitrobenzene as a positive control, when compared with the control values, there were no pathologically relevant differences with the electromagnetic field at any exposure levels at either age. Vascular permeability, measured with reference to transfer of FITC-dextran, was not affected by electromagnetic field exposure.
Thus, these data indicate that local exposure of the head to 1439 MHz electromagnetic field exerts no adverse effects on the blood-brain barrier in immature and young rats.
(Study character: medical/biological study, experimental study, full/main study)
Study funded by
- Association of Radio Industries and Businesses (ARIB), Japan
Glossary: adult, albumin, animal, biological, biosynthesis, blood-brain barrier, brain, CNS, degenerative, DNA, electromagnetic field, endpoint, exposure, expression, Fischer 344, FITC, full/main study, genes, gliosis, glycoprotein, histopathological, immunohistochemical, in vitro, kidneys, lesions, liver, MHz, mobile communication, molecular, morphological, mRNA, neurological, organ, organism, partial body exposure, PDC, permeability, positive control, protein, pulsed, PW, rats, RNA, RT-PCR, SAR, species, strain, symptoms, TDMA, tissue, vascular
- Sirav B et al. (2011): Effects of radiofrequency radiation exposure on blood-brain barrier...
- Sirav B et al. (2009): Blood-brain barrier disruption by continuous-wave radio frequency radiation.
- Nittby H et al. (2009): Increased blood-brain barrier permeability in mammalian brain 7 days after...
- Masuda H et al. (2009): Effects of 915 MHz electromagnetic-field radiation in TEM cell on the...
- Grafstrom G et al. (2008): Histopathological examinations of rat brains after long-term exposure to...
- Eberhardt JL et al. (2008): Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28...
- Masuda H et al. (2007): Effects of acute exposure to a 1439 MHz electromagnetic field on the...
- Masuda H et al. (2007): Effects of subchronic exposure to a 1439 MHz electromagnetic field on the...
- Kumlin T et al. (2007): Mobile phone radiation and the developing brain: behavioral and morphological...
© 1997 - 2013, Research Center for Bioelectromagnetic Interaction (femu - RWTH Aachen University, Germany).
The informational contents of the EMF-Portal are available free of charge for personal and strictly non-commercial purposes. The informational contents of the EMF-Portal may be retrieved, read or printed, but not (i) copied, (ii) changed or (iii) saved in any format, neither electronically nor on other storage media. Permissions for publication, reproduction, commercial purposes or third party propagation of contents of the EMF-Portal – including partial excerpts or revised formats – have to be obtained from the femu Aachen University-copyright holders. By retrieving, reading or printing these documents you expressly state your agreement with all conditions in the fine print.