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Medical/biological Study (experimental study)

Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. med./biol.

By: Kuribayashi M, Wang J, Fujiwara O, Doi Y, Nabae K, Tamano S, Ogiso T, Asamoto M, Shirai T
Published in: Bioelectromagnetics 2005; 26 (7): 578 - 588 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To study whether electromagnetic field exposure causes any damage of blood-brain barrier in rats with ages equivalent to the time of blood-brain barrier genesis and the young adult.
Background/further details:
Immature (4 weeks old) and young (10 weeks old) rats were used.

Endpoint

Exposure
General category: mobile communication system, PDC, TDMA

Field characteristicsParameters
1439 MHz
pulsed (PW)
exposure duration: repeated daily exposure, 90 min/day, 6 days/week, for 1 or 2 weeks
SAR: 2 W/kg average over mass (brain)
SAR: 6 W/kg average over mass (brain)
SAR: 0.29 W/kg max value (whole body)

FIELD View further expo parameters

Exposed system:
animal (species/strain): rat/Fischer 344
partial body exposure: head (nose)

Methods
Endpoint/Measurement parameters/Methodology

investigated material: isolated bio./chem. substance (in vitro), DNA/RNA (in vitro), tissue slices (in vitro), isolated organ (in vitro)
investigation on living organism
investigated organ system: brain/CNS, liver, kidneys

time of investigation: during and after exposure

Main outcome of study (according to author)
Although expression of the three genes was decreased after administration of 1,3-dinitrobenzene as a positive control, when compared with the control values, there were no pathologically relevant differences with the electromagnetic field at any exposure levels at either age. Vascular permeability, measured with reference to transfer of FITC-dextran, was not affected by electromagnetic field exposure.
Thus, these data indicate that local exposure of the head to 1439 MHz electromagnetic field exerts no adverse effects on the blood-brain barrier in immature and young rats.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • Association of Radio Industries and Businesses (ARIB), Japan

Related articles i
Glossary: adult, albumin, animal, biological, biosynthesis, blood-brain barrier, brain, CNS, degenerative, DNA, electromagnetic field, endpoint, exposure, expression, Fischer 344, FITC, full/main study, genes, gliosis, glycoprotein, histopathological, immunohistochemical, in vitro, kidneys, lesions, liver, MHz, mobile communication, molecular, morphological, mRNA, neurological, organ, organism, partial body exposure, PDC, permeability, positive control, protein, pulsed, PW, rats, RNA, RT-PCR, SAR, species, strain, symptoms, TDMA, tissue, vascular

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