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Medical/biological Study (experimental study)

Sinusoidal 50 Hz, 500 microT magnetic field has no acute effect on urinary 6-sulphatoxymelatonin in Wistar rats. med./biol.

By: Bakos J, Nagy N, Thuroczy G, Szabo LD
Published in: Bioelectromagnetics 1995; 16 (6): 377 - 380 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To investigate the effect of a 50 Hz magnetic field (MF) exposure on melatonin production in rats.
Background/further details:
6-sulphatoxymelatonin is the major metabolite of melatonin and can be determined easily non-invasively in excreted urine.
A total of 20 adult rats were used (10 male and 10 female, divided into 2 groups: magnetic field-exposed (500 µT) and sham exposed (5 µT, stray field)). A light (9 h)/dark (15 h) cycle was maintained (light on at 7 a.m./light off at 4 p.m.). Urine was collected twice a day (i.e. at the end of the dark phase and light phase, respectively) over a period of 5 consecutive days. The magnetic field was turned on at 7 a.m. on day 3 and turned off at 7 a.m. on day 4 (total magnetic field exposure time 24 h).

Endpoint

Exposure
General category: magnetic field, 50/60 Hz (AC)

Field characteristicsParameters
50 Hz
exposure duration: 24 h
magnetic flux density: 5 µT effective value (cage located in the stray field)
magnetic flux density: 500 µT effective value (at the center of the cage)

FIELD View further expo parameters

Exposed system:
animal (species/strain): rat/Wistar
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

investigated material: isolated bio./chem. substance (in vitro), 6-sulphatoxymelatonin
investigation on living organism

time of investigation: before, during and after exposure

Main outcome of study (according to author)
No significant changes in the excretion of 6-sulphatoxymelatonin during or after magnetic field exposure could be observed.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • not stated/none

This study was replicated by iRelated articles i
Glossary: 6-sulphatoxymelatonin, 50 Hz, AC, adult, animal, biological, effective value, endocrine, endpoint, excretion, exposed, exposure, full/main study, invasively, in vitro, magnetic field, magnetic flux density, melatonin, metabolism, metabolite, organism, radioimmunoassay, rat/Wistar, rats, sham exposed, significant, species, strain, urine, whole body exposure

© 1997 - 2013, Research Center for Bioelectromagnetic Interaction (femu - RWTH Aachen University, Germany).

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