Medical/biological Study (experimental study)
Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. med./biol. By: Özgüner F, Oktem F, Armagan A, Yilmaz R, Koyu A, Demirel R, Vural H, Uz E
Published in: Mol Cell Biochem 2005; 276 (1-2): 31 - 37 ( PubMed Entry , Journal web site )
Aim of study (according to author)
To compare the protective effects of melatonin and CAPE against 900 MHz electromagnetic field-induced renal tubular injury.
Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. Melatonin and CAPE were found to be potent free radical scavengers and antioxidants.
ROS such as superoxide and nitric oxide may contribute to the pathophysiology of electromagnetic irradiation-induced renal impairment.
General category: mobile phone
FIELD View further expo parameters
animal (species/strain): rat/Sprague-Dawley
whole body exposure
Methodsinvestigated material: kidney tissue homogenates; urine samples
organ system(s): kidney
time of investigation: after exposure
Main outcome of study (according to author)
Urinary NAG and renal malondialdehyde were increased in electromagnetic field exposed animals while both melatonin and CAPE caused a significant reduction in the levels of these parameters but the effect of melatonin was more potent than that of CAPE. Likewise, renal superoxide dismutase and glutathione peroxidase activities were decreased in exposed rats while melatonin caused a significant increase in the activities of these antioxidant enzymes but CAPE did not.
In conclusion, melatonin and CAPE prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by mobile phone (900 MHz). Nevertheless, melatonin seems to be a more potent antioxidant in comparison to CAPE in kidney.
(Study character: medical/biological study, experimental study, full/main study)
Study funded byRelated articles
- Aynali G et al. (2013): Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal...
- Khalil AM et al. (2012): 8-Oxo-7, 8-dihydro-2'-deoxyguanosine as a biomarker of DNA damage by mobile...
- Gholampour F et al. (2011): Chronic Exposure to Extremely Low Frequency Electromagnetic Field Induces Mild...
- Esmekaya MA et al. (2011): 900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on...
- Imge EB et al. (2010): Effects of mobile phone use on brain tissue from the rat and a possible...
- Koyu A et al. (2009): The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative...
- Guney M et al. (2007): 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in...
- Koylu H et al. (2006): Melatonin modulates 900 Mhz microwave-induced lipid peroxidation changes in rat...
- Özgüner F et al. (2006): Protective effects of melatonin and caffeic acid phenethyl ester against...
- Oral B et al. (2006): Endometrial Apoptosis Induced by a 900-MHz Mobile Phone: Preventive Effects of...
- Koyu A et al. (2005): Caffeic Acid Phenethyl Ester Modulates 1800 MHz Microwave-Induced Oxidative...
- Özgüner F et al. (2005): Mobile phone-induced myocardial oxidative stress: protection by a novel...
- Özgüner F et al. (2005): A novel antioxidant agent caffeic acid phenethyl ester prevents long-term...
- Oktem F et al. (2005): Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone:...
- Kim MJ et al. (2004): Green tea catechins protect rats from microwave-induced oxidative damage to...
Glossary: animals, antioxidant, biological, biosynthesis, CAPE, catalase, CW, electromagnetic, electromagnetic field, endpoint, enzymes, exposed, exposure, full/main study, glutathione peroxidase, homogenates, induced, injury, irradiation, lipid peroxidation, malondialdehyde, marker, mean value, melatonin, MHz, mobile phone, molecular, nitric oxide, oxidative, oxidative stress, pathophysiology, power, power flux density, rat/Sprague-Dawley, rats, reduction, renal, ROS, SAR, significant, species, spectrophotometry, strain, superoxide, superoxide dismutase, tissue, tubular, urinary, whole body exposure
© 1997 - 2013, Research Center for Bioelectromagnetic Interaction (femu - RWTH Aachen University, Germany).
The informational contents of the EMF-Portal are available free of charge for personal and strictly non-commercial purposes. The informational contents of the EMF-Portal may be retrieved, read or printed, but not (i) copied, (ii) changed or (iii) saved in any format, neither electronically nor on other storage media. Permissions for publication, reproduction, commercial purposes or third party propagation of contents of the EMF-Portal including partial excerpts or revised formats have to be obtained from the femu Aachen University-copyright holders. By retrieving, reading or printing these documents you expressly state your agreement with all conditions in the fine print.