この研究は、6か月間、1日おきに、50 Hz磁界の5分間ばく露を継続して受けたラットの肺および肝臓の組織に誘発された酸化的損傷、およびそれに対する亜鉛補給の効果を調べた。24匹の成獣の雄のSprague-Dawleyラットを同数の3群に分けた。すなわち、対照群、磁界ばく露群、磁界ばく露+亜鉛補給群である。6か月間の処置の終了時に全ラットを屠殺して肺および肝臓の組織試料を採取し、MDAはTBARS法で、GSHはビウレット法で、亜鉛レベルは原子発光によりそれぞれ測定した。その結果、磁界ばく露群の肺および肝臓組織のMDAレベルは、対照群および磁界ばく露+亜鉛補給群のレベルより有意に高く、磁界ばく露+亜鉛補給群のレベルは対照群より有意に高かった；GSHレベルについては、磁界ばく露+亜鉛補給群が、対照群および磁界ばく露群より有意に高く、磁界ばく露群は対照群より有意に高かった；肝臓および肺組織の亜鉛レベルは、磁界ばく露+亜鉛補給群で最も高く、磁界ばく露群で最も低かった、と報告している。
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To investigate the effects of zinc supplementation on the oxidative damage in lung and liver tissues of rats exposed to an extremely low frequency magnetic field.
Three groups of rats were examined (n=8 per group): 1.) control group, 2.) magnetic field exposure and 3.) magnetic field exposure + daily zinc supplementation (injection of 3 mg zinc per kg body weight for 6 month).
rats were divided into the following three groups: i) sham EMF exposure ii) EMF exposure iii) EMF exposure + exposure to 3 (mg/kg)/day zinc sulphate
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 5 min every other day during 6 months |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | rats kept in 35 cm x 25 cm x 25 cm polyvinyl chloride cages with a single turn of 0.3 mm diameter copper wire wound around them for generation of the magnetic field; mean temperature 22°C; relative humidity 55% to 60% |
| Sham exposure | A sham exposure was conducted. |
In the exposure group, the lipid peroxidation in the lung and liver was significantly increased compared to the control group. A supplementation of zinc significantly lowered the lipid peroxidation compared to the exposure group without zinc, but the level of lipid peroxidation remained significantly higher in comparison to the control group.
The level of glutathione was significantly increased in the lung and liver of exposed rats when compared to the control group. A further significant increase in the concentration of glutathione was observed in exposed rats with zinc supplementation when compared to the exposure group without zinc.
In the lung and liver tissues of exposed rats, the content of zinc was significantly decreased in comparison to the control group, while in the lung and liver tissues of exposed rats with zinc supplementation the zinc content was significantly increased.
The authors conclude that exposure of rats to extremely low frequency magnetic fields could induce tissue damages in the lung and liver and that zinc supplementation could attenuate these damages.
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