研究のタイプ: 医学／生物学の研究 (experimental study)

[雌雄の幼若ウサギにおけるDNA及び脂質のダメージに対する無線周波放射の影響] med./bio.

The effect of radiofrequency radiation on DNA and lipid damage in female and male infant rabbits

著者: Guler G, Tomruk A, Ozgur E, Sahin D, Sepici A, Altan N, Seyhan N
掲載誌: Int J Radiat Biol 2012; 88 (4): 367-373
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本研究では、雌雄のニュージーランド種の白色ウサギを対象に、雌は7日間、雄は14日間、1800MHzのGSM様RF信号に15分／日、子宮内（妊娠期間15日目から22日目）及び／または子宮外（生後1ヵ月時点）でばく露させ、脂質過酸化とDNA損傷を調べるため、月齢1ヶ月の時点で全てのウサギの肝臓について生化学的分析を実施した。2つの時期のばく露の有無によって分けられた4群を比較した結果、RFばく露下では、雌雄いずれのウサギの肝組織においても脂質過酸化レベルの増加が見られた。RFにばく露させた雌のウサギでは、非ばく露ウサギに比べ肝臓8-ヒドロキシ-2'-デオキシグアノシン（8-OHdG）の増加も見られたが、RFにばく露させた雄のウサギでは肝臓8-OHdGレベルに変化は見られなかった。著者らは、GSM様のRF放射は、実験動物モデルであるウサギにおいて、構造的生体分子に対するフリーラジカルの攻撃を増強し、生化学的変化を誘発するかも知れないと結論している。

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研究目的(acc. to editor)

To study the effects of radiofrequency electromagnetic fields on the development of young rabbits.

詳細情報

Rabbits were exposed during the gestational phase (intrauterine; from 15th to 22nd day of gestation) and/or in the age of one month (extrauterine exposure). A total of 72 female (n=36) and male (n=36) rabbits were randomly divided into four groups: 1) sham exposure group, 2) no intrauterine exposure, but extrauterine exposure, 3) intrauterine exposure only (no extrauterine exposure) and 4) intrauterine and extrauterine exposure.
According to the authors, female rabbits were exposed during 7 days, whereas males were exposed during 14 days (however, this is contradictory to the data on the groups above (remark of EMF-Portal editor)).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 min/day on 7 days (female) or 14 days (male)

General information

animals were treated in the following four groups: i) sham exposure ii) EMF exposure at the age of one month iii) intrauterine EMF exposure between day 15 and day 22 of gestation iv) intrauterine EMF exposure between day 15 and day 22 of gestation + EMF exposure at the age of one month

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min/day on 7 days (female) or 14 days (male)
Modulation
Modulation type pulsed
Pulse width 0.576 ms
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 20 cm
チャンバの詳細 shielded room as exposure chamber
ばく露装置の詳細 signal generator connected via a 2 m long cable to the horn antenna; cage with one animal placed under the antenna's aperture
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 0.1 W - 測定値 - -
SAR 1.8 W/kg - 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした臓器系:
  • liver
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Female rabbits: Malondialdehyde levels were significantly increased in group 4 (intrauterine and extrauterine exposure) compared with the sham exposed group and group 3 (intrauterine exposure only). The FOX assay did not reveal any significant differences between the groups. The 8-hydroxy-2-deoxyguanosine levels were significantly increased in groups 2 (extrauterine exposure only) and 4 compared with the sham exposed group and in group 4 compared with group 3.
Male rabbits: Malondialdehyde levels were significantly decreased in group 3 (intrauterine exposure only) compared with the sham exposed group and group 4 (intrauterine and extrauterine exposure). The FOX assay revealed significantly increased levels in group 3 compared with groups 1 and 4. The 8-hydroxy-2-deoxyguanosine levels did not reveal any significant differences between the groups.
GSM-like radiofrequency exposure may induce biochemical changes in the liver tissue of young rabbits.

研究の種別:

研究助成

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