この研究は、微小電極と電圧クランプ技術を改造して、導波管装置内で900MHz電磁界ばく露中の神経細胞(淡水産巻貝ヨーロッパモノアラガイ)の自発性電気活動とイオン電流を記録する実験装置を開発した。電磁界は、0.5-11パルス/秒で変調したパルス波(PW)、または連続波(CW)を用いた。その結果、PWでは、数W/kgのSARで神経細胞の発火率に高速でバースト様の変化が見られた;この変化はPWにのみ見られたが、変調周波数には依存せず、SAR閾値は0.5 W/kg付近であった;CWでは、同じSARにおいて発火率に影響がなかった;アセチルコリン、ドーパミン、セロトニン、GABAの受容体の活性化は、PWおよびCWで影響が無かった、と報告している。
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The study is concerned with the appearance of bursting in the spontaneous activity of pacemaker neurons in response to pulsed waves and continuous wave radiation by microwaves.
周波数 | 900 MHz |
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タイプ |
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特性 |
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ばく露時間 | continuous for up to 15 min |
Modulation type | pulsed |
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Duty cycle | 4 % |
Repetition frequency | 100 Hz |
Additional information |
Pulse rates used were 0.5, 2.5, 6, 16, 40, and 100 Hz. |
ばく露の発生源/構造 | |
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チャンバの詳細 | The experimental techniques and systems were identical to those described in detail by Alekseev et al. [1986]. |
ばく露装置の詳細 | The holding chamber was inserted into the center of a waveguide through an access port that was covered by a metallic mesh (1 x 1 mm) during the experiment. |
Additional information | The temperature of the preparation was controlled by a flow of the medium through the chamber and did not rise by more than 0.1 °C up to an SAR of 20 W/kg. A desired increase of temperature was achieved by heating the medium by 3 °C and regulating the flow rate. |
測定量 | 値 | 種別 | Method | Mass | 備考 |
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SAR | 4 W/kg | mean | 測定値 | - | 0.5-4 W/kg |
周波数 | 900 MHz |
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タイプ |
|
特性 |
|
ばく露時間 | continuous for up to 10 min |
Modulation type | CW |
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ばく露の発生源/構造 |
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測定量 | 値 | 種別 | Method | Mass | 備考 |
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SAR | 15 W/kg | mean | 測定値 | - | 0.5-15 W/kg |
It was found that pulsed waves but not continuous waves elicit bursting responses of neurons. Within the limits of experimental error the effect did not depend on the modulation frequency, but it was sensitive to the SAR. Mediator-induced, current activation of acetylcholine, serotonin, dopamine, or GABA receptors of the neuronal soma was not altered during exposures (continuous wave or pulsed waves) and could not have been responsible for the bursting effect.
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