研究のタイプ: 医学／生物学の研究 (experimental study)

[非電離放射線への出生前ばく露：妊娠結末、末梢B細胞分画、抗体産生に対するWiFi信号の影響] med./bio.

Prenatal Exposure to Non-ionizing Radiation: Effects of WiFi Signals on Pregnancy Outcome, Peripheral B-Cell Compartment and Antibody Production

著者: Sambucci M, Laudisi F, Nasta F, Pinto R, Lodato R, Altavista P, Lovisolo GA, Marino C, Pioli C
掲載誌: Radiat Res 2010; 174 (6): 732-740
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この研究は、WiFi信号への出生前（子宮内）ばく露が妊娠結果および抗体産生を含む免疫B細胞コンパートメントに与える影響を調査した。交尾後の（膣栓陽性の）雌マウス16匹を同数の3群に分けた：ケージ対照群、擬似ばく露群、マイクロ波ばく露群（2.45GHzのWiFi信号、全身平均SAR：4W/kg、交尾5日後から14日間連続で1日2時間ばく露）。その結果、交尾成功率、母マウス1匹当たりの新生仔数、出生時体重にWiFi信号ばく露の影響は見られなかった、と報告している。次に、新生仔マウスが5週齢（幼若時）または26週齢（成熟時）になった時点で免疫学的検査を行った。その結果、脾臓細胞数、B細胞頻度、抗体血清レベルについて、ばく露に起因する差は見られなかった、と報告している。

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研究目的（著者による）

To study the effects of prenatal (in utero) exposure to WiFi signals on pregnancy outcome and some immunological parameters.

詳細情報

16 mated female mice were assigned to each of the following groups: cage control, sham exposed and microwave-exposed group. After delivery newborn mice were left to grow until 5 or 26 weeks of age when they were killed and immunological analyses were performed.
To maximize the possibility of finding an effect, animals were exposed to a very high SAR (4 W/kg) that exceeds any realistic scenario of human exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45–2.473 GHz
ばく露時間: continuous for 2 h/day on 14 consecutive days, starting 5 days after mating, ending one day before expected delivery

ばく露1

主たる特性
周波数 2.45–2.473 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day on 14 consecutive days, starting 5 days after mating, ending one day before expected delivery
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 commercial WiFi access point connected to a notebook via LAN and communicating with a PC using single channel transmission with channel 11; mice placed with the posterior part on the side of the field origin and maintained with the caudal axis parallel to the direction of field propagation; daily clockwise rotation of the eight animals inside the 120 cm long TEM cell
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 4 W/kg - 測定値 whole body -
Additional parameter details

The following numerical SARs were obtained using a realistic model based on a TC scan. In dam 2 the presence (50%) of amniotic liquid (er 5 75.0 and s 5 2.8 S/m at 2450 MHz) was considered: Dam 1: whole-body SAR = 3.3 W/kg, average SAR in the uterus = 3.07 +/- 1.93 W/kg Dam 2: whole-body SAR = 3.29 W/kg, average SAR in the uterus = 4.33 +/- 2.21 W/kg

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

No effects due to exposure to WiFi signals during pregnancy on mating success, number of newborns per dam and body weight at birth were found.
No differences due to exposure were found in spleen cell number, B cell frequency or antibody serum levels. When stimulated in vitro with LPS, B cells from all groups produced comparable amounts of IgM and IgG, and proliferated at a similar level. All these findings were consistently observed in the female and male offspring at both juvenile (5 weeks) and adult (26 weeks) ages. Stress-associated effects (e.g. comparison of cage control and restrained rats of the other two groups) as well as age- and/or sex-related differences were observed for several parameters.
In conclusion, the data did not show any effect on pregnancy outcome or any early or late effects on B cell differentiation and function due to prenatal exposure to WiFi signals.

研究の種別:

研究助成

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