この研究は、培養C3H 10T 1/2細胞を用いて、携帯電話の高周波（RF）放射へのばく露が遺伝子発現の変化を引き起こすか否かを調べた。SARが5 W / kgの24時間ばく露を与えた。ばく露した細胞と擬似ばく露した対照細胞からRNAを抽出し、マイクロアレイAffymetrix U74Av2 Genechipを用いた遺伝子発現解析を行った。0.68 GyのX線にばく露後4時間の回復期を経た細胞を陽性対照として使用した。その結果、RF放射ばく露群で誘発された遺伝子発現変化の数は、擬似ばく露群vs擬似ばく露群の比較に基づいて予測される擬似陽性の数よりも多くなかった；対照的に、X線照射の陽性対照では、擬似ばく露群vs擬似ばく露群の比較に基づく擬似陽性の数に比べ、発現レベルが変化したプローブセットの数は多かった、と報告している。
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To study if exposure to cell phone radiofrequency irradiations induce changes in gene expression.
The experiments were repeated three times each for both CDMA and FDMA exposures.
Cells exposed to 0.68 Gy of X-rays were used as positive controls.
A detailed description of the RTL device and its environmental controls has been given in several publications [Moros et al., 1998 and 1999; Pickard et al., 1999 and 2000].
| 周波数 | 835.62 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 24 h |
| Additional information | FDMA |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
FDMA, dithered ± 0.015 MHz |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | The radial transmission line (RTL) was formed by two horizontal parallel electrically conducting plates. A central conical aluminium antenna emitted TEM waves radially outward that were terminated by an annulus of RF-absorbing foam. The thermally conductive aluminium bottom plate (6 mm thick) minimised temperature gradients among the exposed flasks placed equidistantly around the antenna. The temperature of the culture media during RF and sham exposure was 37 ± 0.3°C [Moros et al., 1999]. |
| ばく露装置の詳細 | Both powered and sham RTLs were loaded with 16 T75 culture flasks containing 40 ml of culture medium, 15 of them being dummy flasks. |
| Sham exposure | A sham exposure was conducted. |
| Additional information | For positive control, cultured cells were first maintained in the incubator for an additional 24 h (to mirror the length of RF exposure), then irradiated with 0.68 Gy of X-rays, and afterwards placed back into the incubator for a 4-h recovery. Another identically treated flask of cells was sham exposed in the X-ray irradiator. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 5 W/kg | average over time | - | - | ± 2.1 W/kg |
| 周波数 | 847.74 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 24 h |
| Additional information | CDMA |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 5 W/kg | average over time | - | - | ± 2.1 W/kg |
The number of gene expression changes induced by irradiation was not greater than the number of false positives expected based on a sham exposure versus sham exposure comparison.
In contrast, the X-rays radiated samples showed higher number of gene expression changes than in the sham exposure versus sham exposure comparison.
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