Studientyp:
Epidemiologische Studie
Proximity to overhead power lines and childhood leukaemia: an international pooled analysis
epidem.
[Wohnnähe zu Hochspannungsfreileitungen und Kinderleukämie: eine internationale gepoolte Analyse]
Von:
Amoon AT, Crespi CM, Ahlbom A, Bhatnagar M, Bray I, Bunch KJ, Clavel J, Feychting M, Hémon D, Johansen C, Kreis C, Malagoli C, Marquant F, Pedersen C, Raaschou-Nielsen O, Röösli M, Spycher BD, Sudan M, Swanson J, Tittarelli A, Tuck DM, Tynes T, Vergara X, Vinceti M, Wünsch-Filho V, Kheifets L
Veröffentlicht in: Br J Cancer 2018; 119 (3): 364-373
Ziel der Studie (lt. Autor)
Weitere Details
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(Odds Ratio (OR))
Exposition
Abschätzung
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
Abstand zu Hochspannungsfreileitung: ≥ 300 m
|
|
Gruppe 2
|
Abstand zu Hochspannungsfreileitung: 150 - < 300 m
|
|
Gruppe 3
|
Abstand zu Hochspannungsfreileitung: 50 - < 150 m
|
|
Gruppe 4
|
Abstand zu Hochspannungsfreileitung: < 50 m
|
|
Referenzgruppe 5
|
Abstand zu ≥ 200 kV Hochspannungsfreileitung: ≥ 300 m
|
|
Gruppe 6
|
Abstand zu ≥ 200 kV Hochspannungsfreileitung: 150 - < 300 m
|
|
Gruppe 7
|
Abstand zu ≥ 200 kV Hochspannungsfreileitung: 50 - < 150 m
|
|
Gruppe 8
|
Abstand zu ≥ 200 kV Hochspannungsfreileitung: < 50 m
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Beobachtungszeitraum:
1960 - 2014
-
Studienort:
Brasilien, USA, Dänemark, Frankreich, Italien, Norwegen, Schweden, Schweiz, Australien, Großbritannien
Fallgruppe
Kontrollgruppe
Studiengröße
|
Fälle |
Kontrollen |
| Gesamtzahl |
30.500 |
69.594 |
| Anzahl auswertbar |
27.143 |
65.265 |
Statistische Analysemethode:
(
Anpassung:
- Alter
- Geschlecht
- sozioökonomischer Status
- Mobilität, Wohnungsart, Verkehr, Umgebung (Stadt/Land), berechnete oder gemessene Magnetfelder
)
Ergebnisse (lt. Autor)
Es wurde kein Zusammenhang zwischen Kinderleukämie und der Wohnnähe zur nächstgelegenen Hochspannungsfreileitung unabhängig von der Spannung beobachtet (Gruppe 2-4). Ein nicht-signifikant erhöhtes Risiko wurde bei Kindern beobachtet, die < 50 m zu einer ≥ 200 kV-Hochspannungsfreileitung gewohnt hatten (Gruppe 8: OR 1,33; KI 0,92-1,93), dies war bei Kindern mit einer Diagnose im Alter bis zu 5 Jahren höher. Der Zusammenhang konnte nicht durch die Exposition bei höheren magnetischen Flussdichten (≥ 0,4 µT) oder durch andere Confounder erklärt werden.
Die Autoren schlussfolgerten, dass in dieser ersten umfangreichen gepoolten Analyse zu Kinderleukämie und der Wohnnähe zu Hochspannungsfreileitungen ein kleines, nicht-signifikantes Risiko für Kinder, die < 50 m zu einer ≥ 200 kV-Hochspannungsfreileitung gewohnt hatten, gefunden wurde, dass nicht mit höheren Magnetfeldern erklärt werden konnte. Die Gründe für das erhöhte Risiko, das in dieser und vielen anderen Studien gefunden wurde, müssen noch aufgeklärt werden.
Studie gefördert durch
-
Electric Power Research Institute (EPRI), USA
Themenverwandte Artikel
-
Amoon AT et al.
(2022):
Pooled analysis of recent studies of magnetic fields and childhood leukemia
-
Seomun G et al.
(2021):
Exposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis
-
Núñez-Enríquez JC et al.
(2020):
Extremely Low-Frequency Magnetic Fields and the Risk of Childhood B-Lineage Acute Lymphoblastic Leukemia in a City With High Incidence of Leukemia and Elevated Exposure to ELF Magnetic Fields
-
Auger N et al.
(2019):
Residential exposure to electromagnetic fields during pregnancy and risk of child cancer: A longitudinal cohort study
-
Crespi CM et al.
(2019):
Childhood leukemia risk in the California Power Line Study: Magnetic fields versus distance from power lines
-
Swanson J et al.
(2018):
Reanalysis of risks of childhood leukaemia with distance from overhead power lines in the UK
-
Bunch KJ et al.
(2016):
Epidemiological study of power lines and childhood cancer in the UK: further analyses
-
Crespi CM et al.
(2016):
Childhood leukaemia and distance from power lines in California: a population-based case-control study
-
Tabrizi MM et al.
(2015):
Increased risk of childhood acute lymphoblastic leukemia (ALL) by prenatal and postnatal exposure to high voltage power lines: a case control study in Isfahan, Iran
-
Salvan A et al.
(2015):
Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study
-
Pedersen C et al.
(2015):
Residential exposure to extremely low-frequency magnetic fields and risk of childhood leukaemia, CNS tumour and lymphoma in Denmark
-
Tabrizi MM et al.
(2015):
Role of electromagnetic field exposure in childhood acute lymphoblastic leukemia and no impact of urinary alpha-amylase - a case control study in Tehran, Iran
-
Ba Hakim AS et al.
(2014):
ELF-EMF correlation study on distance from overhead transmission lines and acute leukemia among children in Klang Valley, Malaysia
-
Bunch KJ et al.
(2014):
Residential distance at birth from overhead high-voltage powerlines: childhood cancer risk in Britain 1962-2008
-
Zhao L et al.
(2014):
Magnetic fields exposure and childhood leukemia risk: a meta-analysis based on 11,699 cases and 13,194 controls
-
Pedersen C et al.
(2014):
Distance from residence to power line and risk of childhood leukemia: a population-based case-control study in Denmark
-
Sermage-Faure C et al.
(2013):
Childhood leukaemia close to high-voltage power lines--the Geocap study, 2002-2007
-
Jirik V et al.
(2012):
Association between Childhood Leukaemia and Exposure to Power-frequency Magnetic Fields in Middle Europe
-
Wünsch Filho V et al.
(2011):
Exposure to magnetic fields and childhood acute lymphocytic leukemia in Sao Paulo, Brazil
-
Kheifets L et al.
(2010):
Pooled analysis of recent studies on magnetic fields and childhood leukaemia
-
Malagoli C et al.
(2010):
Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy
-
Lowenthal RM et al.
(2007):
Residential exposure to electric power transmission lines and risk of lymphoproliferative and myeloproliferative disorders: a case-control study
-
Svendsen AL et al.
(2007):
Exposure to magnetic fields and survival after diagnosis of childhood leukemia: a German cohort study
-
Schüz J et al.
(2007):
Nighttime exposure to electromagnetic fields and childhood leukemia: an extended pooled analysis
-
Kabuto M et al.
(2006):
Childhood leukemia and magnetic fields in Japan: a case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan
-
Draper G et al.
(2005):
Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study
-
Schüz J et al.
(2001):
Residential magnetic fields as a risk factor for childhood acute leukaemia: results from a German population-based case-control study
-
Greenland S et al.
(2000):
A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Childhood Leukemia-EMF Study Group
-
Kleinerman RA et al.
(2000):
Are children living near high-voltage power lines at increased risk of acute lymphoblastic leukemia?
-
UK Childhood Cancer Study Investigators
(2000):
Childhood cancer and residential proximity to power lines
-
Bianchi N et al.
(2000):
Overhead electricity power lines and childhood leukemia: a registry-based, case-control study
-
Ahlbom A et al.
(2000):
A pooled analysis of magnetic fields and childhood leukaemia
-
Green LM et al.
(1999):
A case-control study of childhood leukemia in southern Ontario, Canada, and exposure to magnetic fields in residences
-
Thomas DC et al.
(1999):
Residential magnetic fields predicted from wiring configurations: II. Relationships To childhood leukemia
-
Green LM et al.
(1999):
Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada
-
UK Childhood Cancer Study Investigators
(1999):
Exposure to power-frequency magnetic fields and the risk of childhood cancer
-
Angelillo IF et al.
(1999):
Residential exposure to electromagnetic fields and childhood leukaemia: a meta-analysis
-
McBride ML et al.
(1999):
Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada
-
Dockerty JD et al.
(1998):
Electromagnetic field exposures and childhood cancers in New Zealand
-
Michaelis J et al.
(1998):
Combined risk estimates for two German population-based case-control studies on residential magnetic fields and childhood acute leukemia
-
Tynes T et al.
(1997):
Electromagnetic Fields and Cancer in Children Residing Near Norwegian High-Voltage Power Lines
-
Feychting M et al.
(1993):
Magnetic fields and cancer in children residing near Swedish high-voltage power lines
